Polysaccharide from Laminaria japonica Alleviates Acute Neuroinflammation in Cerebral Ischemia-Reperfusion Injury via Csf3-Related Mechanisms
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By
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Tangming Guan
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Siyu Chen
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Dongbo Jiang
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Weiming Cai
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Huayan Chen
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Yan Wang
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Kefeng Wu
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Xin Zhou
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April 23, 2026
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Clinical Scorecard: Polysaccharide from Laminaria japonica Alleviates Acute Neuroinflammation in Cerebral Ischemia-Reperfusion Injury via Csf3-Related Mechanisms
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | Patients with acute ischemic stroke |
| Care Setting | |
Key Highlights
- Structural characterization confirmed LJP is enriched in fucose, galacturonic acid, glucuronic acid, and sulfate groups.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
- Monitor levels of inflammatory cytokines such as IL-1b, TNFα, and IL-6.
- Assess Csf3 levels in patients to evaluate neuroinflammatory status.
Risks
Patient & Prescribing Data
Patients experiencing acute ischemic stroke
LJP may provide neuroprotective effects by modulating inflammatory pathways.
Clinical Best Practices
- Integrate LJP into treatment protocols for ischemic stroke to address neuroinflammation.
- Utilize transcriptomic analysis to identify potential therapeutic targets in stroke patients.
References
