Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure - Scorecard - MDSpire

Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure

  • By

  • Adnan Hadid

  • Lana A. Shaiba

  • Mona Alkallabi

  • Khalid Nabil Nagshabandi

  • Nora Al-Saud

  • Rodhan Khaled Alnahdi

  • Layan Alsanad

  • Maee Barakeh

  • Naif Ahmed Alshehri

  • Khalid Faisal Alkahtani

  • Adel Abdulaziz Alsuhaibani

  • Abdulmalik Abdulaziz Alharbi

  • June 22, 2026

  • 0 min

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Clinical Scorecard: Clinical Case: Overlap of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis with Ocular and Urogenital Manifestations in an Extremely Preterm Infant After Administration of Broad-Spectrum Antibiotics

At a Glance

CategoryDetail
ConditionStevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN)
Key MechanismsImmune-mediated cytotoxic processes leading to keratinocyte necrosis and epidermal detachment.
Target PopulationExtremely premature infants in the neonatal intensive care unit (NICU).
Care SettingNeonatal intensive care unit (NICU)

Key Highlights

  • SJS/TEN is characterized by widespread keratinocyte necrosis and mucosal involvement.
  • Diagnosis in neonates is complicated by common mimickers.
  • Management includes withdrawal of suspected drugs and supportive care.
  • Mortality remains significant despite supportive measures.
  • This case provides insights into a rare presentation in an extremely premature infant.

Guideline-Based Recommendations

Diagnosis

  • Consider clinicopathologic correlation and skin biopsy to confirm diagnosis.

Management

  • Prompt withdrawal of suspected culprit drugs and meticulous supportive care.

Monitoring & Follow-up

  • Monitor for ocular involvement and other complications.

Risks

  • High mortality risk in extremely premature infants with SJS/TEN.

Patient & Prescribing Data

Extremely premature infants with SJS/TEN overlap.

Adjunctive intravenous immunoglobulin (IVIG) may be considered in management.

Clinical Best Practices

  • Early suspicion of SJS/TEN in at-risk neonates.
  • Multidisciplinary involvement, especially ophthalmology, is crucial.
  • Regular assessment for potential drug triggers during NICU stay.

Related Resources & Content

Original Source(s)

Case Report: Stevens–Johnson syndrome/toxic epidermal necrolysis overlap with ocular and urogenital involvement in an extremely preterm infant following broad-spectrum antibiotic exposure

  • by Adnan Hadid, Lana A. Shaiba, Mona Alkallabi, Khalid Nabil Nagshabandi, Nora Al-Saud, Rodhan Khaled Alnahdi, Layan Alsanad, Maee Barakeh, Naif Ahmed Alshehri, Khalid Faisal Alkahtani, Adel Abdulaziz Alsuhaibani, Abdulmalik Abdulaziz Alharbi

  • June 22, 2026

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