Global research trends and hotspots of short-chain fatty acids in cognitive impairment: a bibliometric analysis based on two databases - Scorecard - MDSpire
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Global research trends and hotspots of short-chain fatty acids in cognitive impairment: a bibliometric analysis based on two databases
Clinical Scorecard: Analyzing Global Research Patterns and Key Areas of Focus on Short-Chain Fatty Acids in Cognitive Impairment: A Bibliometric Study Utilizing Two Databases
At a Glance
Category
Detail
Condition
Cognitive Impairment
Key Mechanisms
Short-chain fatty acids (SCFAs) regulate the central nervous system microenvironment and cognitive function through multiple pathways, influencing the pathological process of cognitive impairment.
Target Population
Individuals with cognitive impairment, including mild cognitive impairment and dementia.
Care Setting
Research and academic settings focusing on cognitive health and gut microbiota.
Key Highlights
Continuous upward trend in publications on SCFAs and cognitive impairment from 2009 to 2025.
China is the leading contributor to research in this field.
High-frequency keywords include 'gut microbiota,' 'Alzheimer’s disease,' and 'neuroinflammation.'
Emerging research frontiers encompass 'drug therapy,' 'microbiology,' and 'chemistry.'
Wenzhou Medical University serves as a core collaboration hub.
Guideline-Based Recommendations
Diagnosis
Cognitive impairment encompasses a spectrum from mild cognitive impairment to dementia.
Management
Exploration of modifiable early targets is essential for managing cognitive impairment.
Monitoring & Follow-up
Monitor cognitive function and associated neuropsychiatric symptoms.
Risks
Key risk factors include age, dietary patterns, lifestyle, metabolic disorders, and gut microbiota dysbiosis.
Patient & Prescribing Data
Individuals experiencing cognitive decline, particularly those at risk for dementia.
Effective disease-modifying treatments for moderate to severe cognitive impairment remain lacking.
Clinical Best Practices
Investigate the role of gut microbiota and SCFAs in cognitive health.
Promote dietary interventions that enhance SCFA production.
