Age-related changes in central corneal thickness and their association with ocular biometric parameters in children - Scorecard - MDSpire
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Investigating the Impact of Age on Central Corneal Thickness and Its Correlation with Ocular Biometric Measurements in Pediatric Patients

  • By

  • Qing Yuan

  • Yawen Bai

  • Zhe Su

  • Ying Zou

  • Yan Lu

  • May 22, 2026

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Clinical Scorecard: Investigating the Impact of Age on Central Corneal Thickness and Its Correlation with Ocular Biometric Measurements in Pediatric Patients

At a Glance

CategoryDetail
Condition
Key MechanismsCCT is influenced by age, axial length, anterior chamber depth, and corneal curvature.
Target Population
Care Setting

Key Highlights

  • Mean CCT was 551.53 ± 32.93 μm in the cohort.
  • CCT positively correlates with age, axial length, and anterior chamber depth.
  • Thinner CCT is associated with myopia and steeper corneal curvature.
  • CCT increases significantly in children aged 3-12 years.
  • No significant change in CCT observed in children aged 13-17 years.

Guideline-Based Recommendations

Diagnosis

  • CCT is a key parameter in diagnosing various ophthalmic conditions.

Management

  • CCT should be considered in pediatric myopia management and orthokeratology safety.

Monitoring & Follow-up

  • Longitudinal assessment of CCT is recommended in children aged 3-12 years.

Risks

  • Thinner CCT is a risk factor for primary open-angle glaucoma.

Patient & Prescribing Data

393 children aged 3 to 17 years with complete ocular biometric data.

Myopic children exhibited thinner CCT compared to non-myopic peers.

Clinical Best Practices

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