Intralesional Vitamin D versus Triamcinolone Acetonide for the Treatment of Keloids: A Systematic Review and Meta-analysis of Randomized Controlled Trials - Scorecard - MDSpire

Intralesional Vitamin D versus Triamcinolone Acetonide for the Treatment of Keloids: A Systematic Review and Meta-analysis of Randomized Controlled Trials

  • By

  • Jiang, Dan

  • Liu, Yalan

  • Li, Sheng

  • Wang, Ximao

  • You, Shunjie

  • May 22, 2026

  • 0 min

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Clinical Scorecard: Comparative Efficacy of Intralesional Vitamin D and Triamcinolone Acetonide in Keloid Treatment: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

At a Glance

CategoryDetail
ConditionKeloids
Key MechanismsIntralesional treatment with vitamin D and triamcinolone acetonide (TAC)
Target PopulationPatients with keloids
Care SettingOutpatient dermatology

Key Highlights

  • TAC showed superior efficacy in scar severity improvement and lesion flattening.
  • Vitamin D had a lower risk of pigmentation changes and skin atrophy.
  • No significant differences in pain, erythema, telangiectasia, or blister formation between treatments.

Guideline-Based Recommendations

Diagnosis

  • Keloids diagnosed based on clinical examination.

Management

  • Consider TAC as first-line treatment; vitamin D as an alternative in select cases.

Monitoring & Follow-up

  • Assess scar improvement using validated scales.

Risks

  • Monitor for steroid-related adverse effects with TAC.

Patient & Prescribing Data

Patients with keloids.

Clinical Best Practices

    Related Resources & Content

    Original Source(s)

    Intralesional Vitamin D versus Triamcinolone Acetonide for the Treatment of Keloids: A Systematic Review and Meta-analysis of Randomized Controlled Trials

    • by Jiang, Dan , Liu, Yalan , Li, Sheng , Wang, Ximao , You, Shunjie

    • May 22, 2026

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