The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neuropathy - Scorecard - MDSpire

The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neuropathy

  • By

  • Genchun Guo

  • Zhenhua Zhu

  • Xin Shao

  • Feixiang Ma

  • Chunyan Xing

  • Yunlan Huang

  • Wanlang Li

  • June 18, 2026

  • 0 min

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Clinical Scorecard: Impact of High-Intensity Interval Training on Glucose Regulation, Inflammation, and Recovery in Individuals with Diabetic Peripheral Neuropathy

At a Glance

CategoryDetail
Condition
Key MechanismsHIIT and MICT improve glucose metabolism and reduce inflammation, with HIIT showing superior effects.
Target Population
Care Setting

Key Highlights

  • HIIT and MICT both improved HbA1c, FPG, and HOMA-IR levels, with HIIT showing more significant improvements.
  • Both training methods reduced inflammatory markers such as TNF-α, IL-6, and CRP, indicating reduced inflammation.

Guideline-Based Recommendations

Diagnosis

    Management

    • Engagement in at least 150 minutes of moderate-intensity or 75 minutes of vigorous-intensity physical activity per week, with specific focus on HIIT.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Patients with type 2 diabetes and DPN.

        HIIT may provide superior benefits over MICT in managing glucose levels and reducing inflammation.

        Clinical Best Practices

        • Incorporate both HIIT and MICT in exercise rehabilitation for DPN, ensuring patient education on risks.

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        Original Source(s)

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