Identification of integrated stress response-related prognostic genes in high-grade serous ovarian cancer using Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing - Scorecard - MDSpire

Identification of integrated stress response-related prognostic genes in high-grade serous ovarian cancer using Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing

  • By

  • Qian Li

  • Fanqiang Kong

  • Penghua Cui

  • Xiujuan Gao

  • Xinrong Zhuang

  • Zhongkai Zhang

  • Tian Tian

  • Guixiang Zhang

  • May 5, 2026

  • 0 min

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Clinical Scorecard: Discovery of Prognostic Genes Associated with the Integrated Stress Response in High-Grade Serous Ovarian Cancer Through Mendelian Randomization and RNA Sequencing Techniques

At a Glance

CategoryDetail
Condition
Key MechanismsIntegrated Stress Response (ISR) and its dual impact on tumor cell proliferation and survival.
Target Population
Care Setting

Key Highlights

  • Add: Implications of the risk model for guiding treatment decisions.

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider targeting ISR-related genes (e.g., NUP35, CASP3) for personalized treatment strategies.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Patients with High-Grade Serous Ovarian Cancer.

        Incorporate ISR-related gene expression in treatment planning to improve outcomes.

        Clinical Best Practices

        • Integrate patient genetic profiles with transcriptomic data for improved treatment planning.

        References

        Original Source(s)

        Identification of integrated stress response-related prognostic genes in high-grade serous ovarian cancer using Mendelian randomization, single-cell RNA sequencing, and bulk RNA sequencing

        • by Qian Li, Fanqiang Kong, Penghua Cui, Xiujuan Gao, Xinrong Zhuang, Zhongkai Zhang, Tian Tian, Guixiang Zhang

        • May 5, 2026

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