Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study - Scorecard - MDSpire
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Development and external validation of a LASSO-based parsimonious nomogram for predicting BPPV recurrence: a multi-center retrospective cohort study
Clinical Scorecard: Creation and external validation of a simplified nomogram utilizing LASSO for forecasting recurrence of BPPV: a multi-center retrospective cohort analysis
At a Glance
Category
Detail
Condition
Benign Paroxysmal Positional Vertigo (BPPV)
Key Mechanisms
Dislodgment of otoconia leading to canalithiasis or cupulolithiasis.
Target Population
Patients diagnosed with BPPV.
Care Setting
Otolaryngology departments in multi-center hospitals.
Key Highlights
1-year recurrence rate of BPPV was 23.97%.
Core variables for recurrence risk: Diabetes Mellitus, Non-posterior canal involvement, 25-hydroxyvitamin D deficiency.
Model demonstrated good discrimination with AUC values of 0.905 (training), 0.872 (internal validation), and 0.853 (external validation).
Calibration curves showed excellent agreement between predicted and observed probabilities.
Nomogram facilitates early identification of high-risk patients.
Guideline-Based Recommendations
Diagnosis
Confirmed diagnosis of BPPV based on clinical criteria.
Management
Canalith Repositioning Procedures (CRP) such as Epley and Barbecue maneuvers.
Monitoring & Follow-up
Regular follow-up to assess recurrence risk and manage symptoms.
Risks
High incidence of recurrence leading to falls and psychological distress.
Patient & Prescribing Data
Patients diagnosed with BPPV from two medical centers.
Focus on personalized recurrence risk stratification using identified core variables.
Clinical Best Practices
Utilize the developed nomogram for risk stratification in clinical practice.
Consider metabolic, anatomical, and nutritional markers in patient assessments.
Implement targeted secondary prevention strategies for high-risk patients.
Dizziness is one of the most common yet complex complaints encountered across primary care, neurology, otolaryngology, and cardiology. It can present as vertigo, imbalance, or nonspecific lightheadedness. It can leave both patients and physicians searching for clear answers.
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