Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation - Scorecard - MDSpire

Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation

  • By

  • Thomas P. Buters

  • Digna T. de Bruin

  • Pieter W. Hameeteman

  • Wouter ten Voorde

  • Hendrika W. Grievink

  • Michelle Osse

  • Marieke L. de Kam

  • Jeffrey Damman

  • Thierry P. P. van den Bosch

  • Elsa Neubert

  • Robert Rissmann

  • Jacobus Burggraaf

  • Naomi Klarenbeek

  • Manon A. A. Jansen

  • Matthijs Moerland

  • May 20, 2026

  • 0 min

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Clinical Scorecard: Initial Immune Reactions to Intradermal Lipopolysaccharide in Healthy Subjects: The Role of Prednisolone in Modulating TLR4-Driven Inflammation

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationHealthy male volunteers aged 18-45.
Care Setting

Key Highlights

  • Add significance of IL-8, IL-6, and IL-1β peaks.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Monitor IL-8, IL-6, and IL-1β levels post-LPS injection.

      Risks

        Patient & Prescribing Data

        Oral prednisolone administered at a dosage of X mg for 2.5 days prior to LPS challenge.

        Clinical Best Practices

        • Evaluate new anti-inflammatory therapies targeting IL-1β and NET formation, such as drug Y and drug Z.

        Related Resources & Content

        Original Source(s)

        Early immune responses to intradermal lipopolysaccharide in healthy volunteers: prednisolone’s impact on TLR4-mediated inflammation

        • by Thomas P. Buters, Digna T. de Bruin, Pieter W. Hameeteman, Wouter ten Voorde, Hendrika W. Grievink, Michelle Osse, Marieke L. de Kam, Jeffrey Damman, Thierry P. P. van den Bosch, Elsa Neubert, Robert Rissmann, Jacobus Burggraaf, Naomi Klarenbeek, Manon A. A. Jansen, Matthijs Moerland

        • May 20, 2026

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