Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease - Scorecard - MDSpire

Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease

  • By

  • Seonghwan Kim

  • Soobin Lee

  • Soyeon Ju

  • Jaewoong Bae

  • Jin Suk Ryu

  • Yerim Heo

  • Wan Jae Choi

  • Kum-Joo Shin

  • Seok-Jin Kim

  • Namphil Kim

  • Hansol Choi

  • Jiyun Park

  • Eunjae Lee

  • Chang Ho Yoon

  • Sunghoon Kwon

  • Junho Chung

  • Mee Kum Kim

  • June 16, 2026

  • 0 min

Share

Clinical Scorecard: Transfer of Gut Microbiota from Autoimmune Dry Eye Model Mice Alters B Cell Receptor Profiles in the Lacrimal Gland and Triggers Disease Development

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationNOD.B10.H2b mice and B6 mice
Care Setting

Key Highlights

  • Remove unsupported conclusion about the gut-ocular immune axis.

Guideline-Based Recommendations

Diagnosis

    Management

    • C
    • l
    • a
    • r
    • i
    • f
    • y
    • a
    • t
    • t
    • r
    • i
    • b
    • u
    • t
    • i
    • o
    • n
    • f
    • o
    • r
    • F
    • M
    • T
    • r
    • e
    • c
    • o
    • m
    • m
    • e
    • n
    • d
    • a
    • t
    • i
    • o
    • n
    • .

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Autoimmune dry eye disease patients.

        Investigational agents targeting autoimmune pathways are being tested.

        Clinical Best Practices

        • Evaluate the role of gut microbiota in autoimmune disease progression

        Related Resources & Content

        Original Source(s)

        Gut microbiota transfer from autoimmune dry eye mice imprints stereotypic B cell receptor repertoires in the lacrimal gland and induces disease

        • by Seonghwan Kim, Soobin Lee, Soyeon Ju, Jaewoong Bae, Jin Suk Ryu, Yerim Heo, Wan Jae Choi, Kum-Joo Shin, Seok-Jin Kim, Namphil Kim, Hansol Choi, Jiyun Park, Eunjae Lee, Chang Ho Yoon, Sunghoon Kwon, Junho Chung, Mee Kum Kim

        • June 16, 2026

        Related Content

        Case report: When Behçet’s disease meets multizonal outer retinopathy and retinal pigment epitheliopathy: longitudinal multimodal imaging of an overlap phenotype

        Case Report: A rare case of ocular giant cell arteritis with bilateral orbital inflammation and diagnostic challenges

        Efgartigimod for generalized myasthenia gravis: a comprehensive review of clinical evidence and future perspectives