High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial ex vivo improvement by ML-7 - Scorecard - MDSpire

High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial ex vivo improvement by ML-7

  • By

  • Jiao Li

  • Jiantao Zhou

  • Qingxu Ha

  • Junwei Gu

  • Hui Yuan

  • Juan Cheng

  • Xiaojun Zha

  • Jingjing Teng

  • Liang Li

  • Junli Ding

  • May 11, 2026

  • 0 min

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Clinical Scorecard: Obesity Induced by High-Fat Diet Disrupts Endothelium-Dependent Relaxation in Rabbits: Link to MLCK Upregulation and Partial Restoration with ML-7 Treatment

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationMale New Zealand White rabbits, 3 months old
Care Setting

Key Highlights

  • Clarify that FMD did not improve despite ML-7 treatment, indicating a potential limitation of the treatment.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

      • Monitor serum lipids (total cholesterol, LDL, HDL, triglycerides) and fasting glucose levels regularly in obese populations.

      Risks

        Patient & Prescribing Data

        ML-7 may offer partial restoration of endothelial function but does not guarantee improved FMD outcomes; individual responses may vary.

        Clinical Best Practices

        • monitoring

        Related Resources & Content

        Original Source(s)

        High-fat diet-induced obesity impairs endothelium-dependent relaxation in rabbits: association with MLCK upregulation and partial ex vivo improvement by ML-7

        • by Jiao Li, Jiantao Zhou, Qingxu Ha, Junwei Gu, Hui Yuan, Juan Cheng, Xiaojun Zha, Jingjing Teng, Liang Li, Junli Ding

        • May 11, 2026

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