Clinical efficacy and safety of porcine fibrin sealant in video-assisted thoracoscopic surgery lobectomy for lung cancer
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By
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Teng Jia
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Ming-hui Yue
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Shu-jing Yin
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Tian-yu She
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Xiao-gang Zhao
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Xiao-jie Gu
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June 1, 2026
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Clinical Scorecard: Effectiveness and Safety of Porcine Fibrin Sealant in Video-Assisted Thoracoscopic Lobectomy for Lung Cancer
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Porcine fibrin sealant (PFS) acts as a biological tissue adhesive, providing a physical barrier and biological scaffold for tissue repair. |
| Target Population | |
| Care Setting | |
Key Highlights
- PFS significantly shortened the duration of chest tube placement (P = 0.036).
- PFS reduced the incidence of pulmonary air leaks (0.0% vs. 5.0%, P = 0.019).
- PFS decreased the occurrence of severely prolonged drainage (0.0% vs. 22.3%, P < 0.001).
- No significant differences in other complications; no allergic reactions reported.
Guideline-Based Recommendations
Diagnosis
- Postoperative pathological diagnosis of primary lung cancer.
Management
- Intraoperative application of PFS during VATS lobectomy.
Monitoring & Follow-up
- Monitor for postoperative complications including pulmonary air leaks and drainage duration.
Risks
- Potential risks include cross-infection and complications from other surgical methods.
Patient & Prescribing Data
345 lung cancer patients who underwent VATS lobectomy between 2017 and 2023.
PFS application is associated with reduced postoperative complications and chest tube duration.
Clinical Best Practices
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