Sanjad–Sakati syndrome: integrated emergency care, long-term management, and expert perspectives—a narrative review
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By
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Meshal Atiyah
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July 14, 2026
Clinical Scorecard: Sanjad–Sakati Syndrome: Comprehensive Emergency Management, Ongoing Care Strategies, and Insights from Specialists—A Review
At a Glance
| Category | Detail |
|---|
| Condition | Sanjad–Sakati Syndrome |
| Key Mechanisms | Autosomal recessive disorder due to mutations in the TBCE gene leading to congenital hypoparathyroidism and multisystem involvement. |
| Target Population | Children with Sanjad–Sakati syndrome, particularly in regions with high consanguinity rates. |
| Care Setting | Pediatric emergency care and long-term management. |
Key Highlights
- Characterized by congenital hypoparathyroidism, persistent hypocalcemia, and growth retardation.
- Emergency management includes urgent calcium correction and airway stabilization.
- Long-term care requires lifelong calcium and vitamin D supplementation.
- Children are at risk for infections and metabolic instability.
- Early biochemical correction and multidisciplinary follow-up are critical.
Guideline-Based Recommendations
Diagnosis
- Early identification of biochemical abnormalities is essential for diagnosis.
Management
- Implement standardized emergency protocols and family-directed action plans.
Monitoring & Follow-up
- Regular metabolic monitoring and renal assessment are necessary.
Risks
- Heightened susceptibility to infections and metabolic crises.
Patient & Prescribing Data
Children diagnosed with Sanjad–Sakati syndrome.
Lifelong calcium and vitamin D supplementation is crucial for management.
Clinical Best Practices
- Coordinate multidisciplinary follow-up to improve outcomes.
- Provide caregiver education to manage the complexities of the syndrome.
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