Evaluating the Efficacy of Negative Pressure Wound Therapy: Is It Beneficial?

Category	Detail
Condition	Surgical site infection (SSI) and delayed wound healing
Key Mechanisms	Negative pressure wound therapy (NPWT) applies suction to wounds to remove exudate, potentially enhances local blood flow, and stimulates fibroblastic activity to promote granulation and tissue healing
Target Population	Patients with surgical wounds healing by primary or secondary intention, including high-risk SSI patients
Care Setting	Hospital and community settings involving surgical wound management

Moderate-certainty evidence suggests NPWT probably reduces SSI compared to standard dressings, but evidence is limited by risk of bias and industry funding.
Recent large NIHR-funded RCTs (SUNRRISE and SWHSI-2) showed no significant benefit of NPWT or incisional NPWT (iNPWT) in reducing SSI or accelerating wound healing.
WHO and NICE guidelines conditionally recommend iNPWT for patients at high risk of SSI, reflecting ongoing uncertainty and need for further robust trials.

Identify patients at high risk of surgical site infection for potential consideration of iNPWT.

Consider use of iNPWT in high-risk patients as per WHO 2018 and NICE 2019 conditional recommendations.
Standard dressings remain appropriate given current evidence showing no clear superiority of NPWT in many contexts.

Monitor wound healing progress and SSI occurrence regardless of dressing type.
Evaluate cost-effectiveness and clinical outcomes continuously as new evidence emerges.

Potential increased healthcare costs without clear benefit in some wound types.
Risk of bias in existing studies necessitates cautious interpretation of NPWT efficacy.

Surgical patients with wounds healing by primary or secondary intention, including emergency laparotomy and foot/leg wounds.

Recent large trials show no significant benefit of NPWT/iNPWT in reducing SSI or accelerating healing; cost-effectiveness not demonstrated.

Use NPWT or iNPWT selectively, prioritizing patients at high risk of SSI.
Remain informed about ongoing and future high-quality trials to guide evidence-based use.
Balance potential benefits against costs and resource constraints in clinical decision-making.
Recognize wound heterogeneity and avoid generalizing NPWT efficacy across all wound types.

Clinical Scorecard: Evaluating the Efficacy of Negative Pressure Wound Therapy: Is It Beneficial?