The mechanism of action and therapeutic potential of macrophages in osteoporosis: from polarization balance to targeted regulation
By
Chuanlong Liu
Tonghao Wang
Zhishuai Ren
Ji Luo
Zhexiang Wang
Yanchen Liang
Bing Peng
May 20, 2026
Clinical Scorecard: Exploring the Role and Therapeutic Promise of Macrophages in Osteoporosis: From Polarization Dynamics to Targeted Interventions
At a Glance
Category Detail
Condition Osteoporosis (OP) Key Mechanisms Imbalance in M1/M2 macrophage polarization affecting bone remodeling and metabolic homeostasis. Target Population Elderly population and postmenopausal women. Care Setting Clinical settings focusing on metabolic bone diseases.
Key Highlights
Osteoporosis affects 18.3% of the global population, with higher prevalence in women. Macrophage polarization dynamics (M1 vs. M2) significantly influence bone metabolism. Chronic inflammation and endocrine factors are critical in osteoporosis pathogenesis. Osteoporotic fractures lead to high mortality rates and economic burdens. Emerging therapies targeting macrophage polarization show promise for osteoporosis treatment. Guideline-Based Recommendations
Diagnosis
Assess bone mineral density and fracture risk in at-risk populations. Management
Consider macrophage-targeted therapies alongside conventional anti-osteoporotic drugs. Monitoring & Follow-up
Regularly evaluate bone density and fracture incidence in treated patients. Risks
Monitor for increased fracture risk and complications from osteoporosis. Patient & Prescribing Data
Primarily postmenopausal women and elderly individuals.
Macrophage polarization modulation may enhance treatment efficacy.
Clinical Best Practices
Incorporate lifestyle modifications to improve mechanical loading on bones. Utilize anti-inflammatory strategies to address chronic inflammation in patients. Related Resources & Content
