Research hotspots and trend of the heart-brain axis by MRI: a bibliometric analysis
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By
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Haoran Wang
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Yang Jia
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Yi Liao
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Linjun Xie
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Wenfeng Jin
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Qianyu Peng
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Huayan Xu
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Rong Xu
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Yingkun Guo
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July 7, 2026
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Clinical Scorecard: Trends and Key Areas of Research on the Heart-Brain Axis via MRI: A Bibliometric Study
At a Glance
| Category | Detail |
|---|
| Condition | Heart-Brain Axis |
| Key Mechanisms | Bidirectional interactions between cardiovascular and central nervous systems affecting neurological and cardiovascular comorbidities. |
| Target Population | Children with congenital heart disease and other neurological disorders. |
| Care Setting | Research and clinical assessment using MRI technologies. |
Key Highlights
- Strong concordance in publication trends between WoSCC and PubMed datasets.
- Identification of four primary research clusters: Technology & Development, Function & Regulation, Risk & Pathology, Hemodynamics & Perfusion.
- High-TLS keywords include MRI, functional connectivity, dementia, and hemodynamics.
- Leading contributors include the United States, Germany, and the United Kingdom.
Guideline-Based Recommendations
Diagnosis
- Utilize MRI for assessing brain structural and functional changes related to heart-brain interactions.
Management
- Focus on interdisciplinary approaches integrating cardiovascular and neurological assessments.
Monitoring & Follow-up
- Implement advanced imaging techniques to track brain developmental trajectories in affected populations.
Risks
- Consider the impact of cardiovascular diseases on cognitive and emotional disturbances.
Patient & Prescribing Data
Children with congenital heart disease and neurological disorders.
MRI is essential for evaluating preoperative structural abnormalities and postoperative neurodevelopmental outcomes.
Clinical Best Practices
- Adopt a systems medicine framework for understanding heart-brain interactions.
- Encourage collaboration across disciplines to enhance research and clinical outcomes.
Related Resources & Content
