Transplacental transfer of anti-malarial antibodies: a systematic review
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By
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Abebe Muche Belete
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Abdouramane Camara
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Taklo Simeneh Yazie
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Lucas N. Amenga-Etego
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Yaw Aniweh
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June 19, 2026
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Clinical Scorecard: Systematic Review of Transplacental Antibody Transfer Against Malaria
At a Glance
| Category | Detail |
|---|
| Condition | Malaria |
| Key Mechanisms | Transplacental transfer of antibodies provides protection to newborns against malaria. |
| Target Population | Pregnant women and newborns |
| Care Setting | Maternal and child health |
Key Highlights
- Pooled prevalence of peripheral malaria in mothers was 31.27%.
- IgG1 and IgG3 were the predominant subclasses transferred efficiently.
- Factors like HIV infection and low birth weight reduce antibody transfer.
- Transplacental transfer efficiency varies by antigen and maternal factors.
- Vaccination strategies may enhance transplacental antibody transfer.
Guideline-Based Recommendations
Diagnosis
- Assess malaria prevalence in pregnant women and newborns.
Management
- Consider maternal vaccination to improve antibody transfer.
Monitoring & Follow-up
- Monitor maternal health and malaria infection status during pregnancy.
Risks
- Identify factors associated with reduced antibody transfer such as HIV and low birth weight.
Patient & Prescribing Data
Pregnant women and their newborns
Vaccination may provide protective antibodies to newborns.
Clinical Best Practices
- Encourage maternal vaccination against malaria.
- Monitor and manage maternal health conditions that affect antibody transfer.
Related Resources & Content
