Global burden and temporal trends of kidney cancer among children from 1990 to 2021: an analysis with projections to 2036
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By
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Kai Liu
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Changlin Yang
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Feng Chen
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Xuhua Qiao
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Yujie Geng
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Chundong Ji
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July 9, 2026
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Clinical Scorecard: Worldwide Impact and Trends in Pediatric Kidney Cancer from 1990 to 2021: A Study with Future Projections to 2036
At a Glance
| Category | Detail |
|---|
| Condition | Childhood Kidney Cancer |
| Key Mechanisms | Predominantly Wilms tumor, with genetic susceptibility playing a significant role. |
| Target Population | Children aged 0–14 years. |
| Care Setting | Global epidemiological analysis. |
Key Highlights
- 9,576 incident cases and 3,063 deaths globally in 2021.
- Age-standardized incidence rate (ASIR) of 0.48 per million person-years.
- Significant decline in disease burden, particularly in females.
- Higher burden observed in children aged 0–4 years.
- Disparities in mortality and DALYs concentrated in lower-SDI countries.
Guideline-Based Recommendations
Diagnosis
- Utilize ICD-10 and ICD-9 codes for identification of KC cases.
Management
- Focus on understanding epidemiological patterns to aid in prevention and management.
Monitoring & Follow-up
- Track incidence, mortality, and DALYs using GBD data.
Risks
- Recognize health inequities and their impact on disease burden in low-SDI countries.
Patient & Prescribing Data
Children aged 0–14 years with kidney cancer.
Survival rates for Wilms tumor are approximately 90%, but significant chronic health issues may arise post-diagnosis.
Clinical Best Practices
- Enhance understanding of pediatric KC epidemiology.
- Address health inequities in lower-income regions.
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