Creation and assessment of a software tool for histoanatomical morphometric evaluation of the intestinal wall in pediatric patients with Hirschsprung’s disease - Scorecard - MDSpire

Creation and assessment of a software tool for histoanatomical morphometric evaluation of the intestinal wall in pediatric patients with Hirschsprung’s disease

  • By

  • Tebin Hawez

  • Tobias Erlöv

  • Christina Granéli

  • Gustav Andersson

  • Tyra Lundberg

  • Emma Fransson

  • Maria Evertsson

  • Magnus Cinthio

  • Pernilla Stenström

  • March 21, 2026

  • 0 min

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Clinical Scorecard: Creation and assessment of a software tool for histoanatomical morphometric evaluation of the intestinal wall in pediatric patients with Hirschsprung’s disease

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPediatric patients with rectosigmoid Hirschsprung’s disease, age below 1 year and body weight not exceeding 10 kilos.
Care Setting

Key Highlights

  • Development of a computer program for efficient histomorphometric analysis.
  • Validation of the program against manual measurements.
  • Focus on inter- and intra-observer reliability.
  • User-friendly interface designed for clinicians.
  • Potential for application in other organs.
  • Clinical implications of software application in practice.

Guideline-Based Recommendations

Diagnosis

    Management

    • Employ the computer program for accurate bowel wall layer measurements.
    • Ensure consistent training for users to minimize variability.
    • Implement specific training protocols for users.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Surgical resection of aganglionic segments is standard treatment, with emphasis on post-operative care.

        Clinical Best Practices

        • Implement semi-automatic assessment to enhance measurement accuracy.
        • Conduct regular training sessions for users of the software.
        • Utilize validated imaging techniques for histopathological analysis.
        • Include periodic software updates based on technological advancements.

        References

        Original Source(s)

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