Analysis of risk factors for hemorrhagic transformation after mechanical thrombectomy in acute anterior circulation large vessel occlusion stroke and construction of a nomogram prediction model - Scorecard - MDSpire

Analysis of risk factors for hemorrhagic transformation after mechanical thrombectomy in acute anterior circulation large vessel occlusion stroke and construction of a nomogram prediction model

  • By

  • Mujie Yao

  • Keqi Lei

  • Yue Wan

  • May 29, 2026

  • 0 min

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Clinical Scorecard: Evaluation of Hemorrhagic Transformation Risk Factors Following Mechanical Thrombectomy in Acute Anterior Circulation Large Vessel Occlusion Stroke and Development of a Predictive Nomogram

At a Glance

CategoryDetail
ConditionHemorrhagic Transformation (HT) after Mechanical Thrombectomy (MT)
Key MechanismsIschemia-reperfusion injury, blood-brain barrier disruption, inflammatory activation, coagulation-fibrinolysis imbalance
Target PopulationPatients with acute anterior circulation large vessel occlusion stroke undergoing mechanical thrombectomy
Care SettingSingle center, retrospective study

Key Highlights

  • Identified six independent risk factors for HT after MT
  • Developed a predictive nomogram with an AUC of 0.880
  • Study included 193 patients with acute anterior circulation LVO
  • HT occurred in 23.32% of patients post-MT
  • Nomogram demonstrated good discrimination and calibration

Guideline-Based Recommendations

Diagnosis

  • HT defined as the emergence of new hemorrhage on imaging within 24–72 hours post-MT

Management

  • Consider risk factors when planning MT and post-procedural care

Monitoring & Follow-up

  • Postoperative imaging to assess for HT within 24–72 hours

Risks

  • HT is associated with poor neurological functional prognosis and clinical outcomes

Patient & Prescribing Data

193 patients with acute anterior circulation LVO

Risk factors include history of alcohol consumption, leukoencephalopathy, elevated GLR, D-dimer, venous blood glucose, and reduced MPV

Clinical Best Practices

  • Utilize the developed nomogram for individualized risk prediction of HT
  • Monitor biochemical indicators and clinical variables pre- and post-MT

Related Resources & Content

Original Source(s)

Analysis of risk factors for hemorrhagic transformation after mechanical thrombectomy in acute anterior circulation large vessel occlusion stroke and construction of a nomogram prediction model

  • by Mujie Yao, Keqi Lei, Yue Wan

  • May 29, 2026

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