Single-center experience of interventional therapy for congenital portal-systemic shunt in children
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By
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Xiangfeng Guo
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Qi Di
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Gang Shen
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July 1, 2026
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Clinical Scorecard: Experience with Interventional Treatment for Congenital Portosystemic Shunt in Pediatric Patients at a Single Center
At a Glance
| Category | Detail |
|---|
| Condition | Congenital Portosystemic Shunt (CPSS) |
| Key Mechanisms | Developmental abnormalities of the portal venous system leading to bypass of hepatic blood flow into systemic circulation. |
| Target Population | Pediatric patients aged 1 to 18 years with confirmed CPSS. |
| Care Setting | Single-center retrospective analysis of interventional therapy. |
Key Highlights
- 73% overall success rate of interventional therapy in pediatric patients.
- Technical success rate of 94.4% in intrahepatic portal-systemic shunt group.
- Improvement rates of liver function parameters: 63% for ALT/AST normalization, 73.7% for bile acids, and 100% for blood ammonia.
Guideline-Based Recommendations
Diagnosis
- Confirmed CPSS by contrast-enhanced Computed Tomography Angiography (CTA) or ultrasound.
Management
- Individualized interventional therapy strategies based on anatomical subtype.
Monitoring & Follow-up
- Postoperative follow-up for 1–12 months to evaluate liver function and complication rates.
Risks
- Mild complications occurred in 3.8% of cases, including puncture site hematoma.
Patient & Prescribing Data
26 pediatric patients with CPSS treated between January 2022 and August 2025.
Interventional techniques included coil embolization and Amplatzer occluder embolization.
Clinical Best Practices
- Preoperative assessment using imaging and hemodynamic measurements.
- Use of temporary balloon occlusion test to assess portal pressure before embolization.
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