Analysis of immune and autophagy-related genes and their regulatory mechanisms in osteoporosis patients post-menopause
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By
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Zhanfeng Zhang
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Jianyou Li
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Kuan Ni
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Chengyin Lei
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Xining Li
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Yunliang Yao
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June 1, 2026
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Clinical Scorecard: Investigation of Immune and Autophagy-Associated Genes and Their Regulatory Roles in Postmenopausal Osteoporosis Patients
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Immune dysregulation and autophagy as identified in the study. |
| Target Population | |
| Care Setting | |
Key Highlights
- Identification of hub genes CDK2, DDIT3, and MAPK8 linked to PMO
- Development of a diagnostic model with high predictive accuracy (AUC = 0.91)
- Significant correlation between hub genes and immune cell infiltration
Guideline-Based Recommendations
Diagnosis
- Utilization of a diagnostic model based on immune-autophagy-related genes as per study findings.
Management
Monitoring & Follow-up
- Assessment of bone mineral density and serum biomarkers as per study findings.
Risks
Patient & Prescribing Data
Focus on findings from the study without unsupported claims.
Clinical Best Practices
Related Resources & Content
