Higher neutrophil count, higher lymphocyte-to-monocyte ratio, and lower platelet-to-lymphocyte ratio are independently associated with postpartum depression symptoms in twin pregnancies - Scorecard - MDSpire
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Higher neutrophil count, higher lymphocyte-to-monocyte ratio, and lower platelet-to-lymphocyte ratio are independently associated with postpartum depression symptoms in twin pregnancies
Clinical Scorecard: Elevated neutrophil levels, increased lymphocyte-to-monocyte ratios, and decreased platelet-to-lymphocyte ratios are independently linked to symptoms of postpartum depression in women with twin pregnancies.
At a Glance
Category
Detail
Condition
Postpartum Depression (PPD)
Key Mechanisms
Immune-inflammatory dysregulation
Target Population
Women with twin pregnancies
Care Setting
Tertiary hospital
Key Highlights
17.14% of women with twin pregnancies exhibited PPD symptoms.
Higher neutrophil and lymphocyte counts, and lower PLR are associated with PPD symptoms.
Multivariable logistic regression indicated significant associations with PPD symptoms.
Guideline-Based Recommendations
Diagnosis
Screen for PPD symptoms using the Edinburgh Postnatal Depression Scale within 4 weeks postpartum.
Management
Consider routine assessment of inflammatory biomarkers in women with twin pregnancies.
Monitoring & Follow-up
Monitor inflammatory markers such as neutrophil, lymphocyte, and platelet counts.
Risks
Increased risk of PPD symptoms associated with higher neutrophil counts and lower PLR.
Patient & Prescribing Data
Women with twin pregnancies delivered between May 2022 and May 2024.
Higher neutrophil count and LMR, and lower PLR may indicate increased risk for PPD.
Clinical Best Practices
Integrate psychosocial and hormonal factors in future studies on PPD.
Utilize low-cost hematological parameters for early identification of PPD.
