Prenatal NSAIDs exposure and childhood kidney disease: a systematic review and meta-analysis
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By
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Xinping Cui
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Rong Feng
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Bin Song
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Qian Zhou
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Yan Zeng
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May 21, 2026
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Clinical Scorecard: Maternal NSAID Use During Pregnancy and Its Association with Kidney Disease in Children: A Comprehensive Review and Meta-Analysis
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Prenatal exposure to NSAIDs potentially increases the risk of kidney disease in offspring, as indicated by the meta-analysis. |
| Target Population | |
| Care Setting | |
Key Highlights
Guideline-Based Recommendations
Diagnosis
Management
- Consider alternative pain management strategies for pregnant women, such as acetaminophen or non-pharmacological methods.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Caution advised in prescribing NSAIDs such as ibuprofen and naproxen during pregnancy due to potential risks.
Clinical Best Practices
- Educate patients on the risks of NSAID use during pregnancy and discuss alternatives.
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