Voice Restoration: Expanding Treatment Options
Advances like autologous platelet-rich plasma (PRP) injections are helping patients with structural disorders of the vocal folds.
Clinical Scorecard: Voice Restoration: Expanding Treatment Options
At a Glance
Category Detail
Condition Vocal fold disorders Key Mechanisms Regenerative therapies including PRP injections and immunotherapy for RRP Target Population Patients with persistent hoarseness, dysphagia, vocal fold scar, atrophy, paralysis, and recurrent respiratory papillomatosis Care Setting USC Voice Center, part of Keck Medicine and the USC Caruso Department of Otolaryngology – Head and Neck Surgery
Key Highlights
Innovative use of autologous PRP injections for vocal fold scar and atrophy FDA approval of Papzimeos for recurrent respiratory papillomatosis (RRP) Multidisciplinary approach integrating medical, surgical, and behavioral therapies Clinical trials demonstrating safety and efficacy of new treatment options Importance of early evaluation and direct visualization of vocal folds Guideline-Based Recommendations
Diagnosis
Early and direct visualization of vocal folds for patients with hoarseness persisting longer than four weeks Management
Use of PRP injections for vocal fold scar refractory to voice therapy Utilization of immunotherapy Papzimeos for RRP Monitoring & Follow-up
Assess patient-reported voice handicap and perceptual voice quality post-treatment Risks
Delaying diagnosis by initiating therapy without visual examination Patient & Prescribing Data
Patients with complex, non-resolving voice and swallowing disorders
Advanced, tissue-sparing techniques available at the USC Voice Center
Clinical Best Practices
Referral to specialized centers for advanced treatment options Integration of speech-language pathology in patient care Use of minimally invasive procedures to preserve normal tissue Related Resources & Content
