Clinical Scorecard: Annual Hematopoietic Stem Cell Transplant Procedures in Europe Exceed 40,000 in 2014
At a Glance
Category
Detail
Condition
Acquired and congenital disorders of the hematopoietic system, immune system disorders, metabolic disorders
Key Mechanisms
Hematopoietic stem cell transplantation (HSCT) using allogeneic or autologous stem cells from various donor types
Target Population
Patients with hematopoietic, immune, and metabolic disorders including pediatric and adult patients
Care Setting
Specialized transplant centers across Europe and affiliated countries
Key Highlights
In 2014, over 40,000 HSCT procedures were performed in Europe and affiliated countries, marking a continuous increase over 20 years.
42% of transplants were allogeneic and 58% autologous; pediatric transplants accounted for approximately 12% of total patients.
The survey achieved a 97% response rate from 656 centers in 49 countries, providing comprehensive data on donor types, indications, and transplant rates.
Guideline-Based Recommendations
Diagnosis
HSCT indicated for acquired and congenital hematopoietic disorders, immune system disorders, and metabolic diseases requiring enzyme replacement.
Management
Selection of donor type includes HLA identical siblings, matched unrelated donors, haploidentical donors, and cord blood stem cells.
Multiple transplant protocols include planned sequential transplants and retransplants for relapse or rejection.
Monitoring & Follow-up
Data collection includes transplant indications, donor type, stem cell source, and subsequent transplants.
Quality control involves validation by reporting teams, cross-checking with registry databases, and national registries.
Risks
Risks include graft rejection, relapse, and complications related to donor mismatches and transplant procedures.
Patient & Prescribing Data
36,469 patients received first HSCT in 2014; 4,400 were pediatric patients under 18 years.
Increasing use of diverse donor types and stem cell sources; rising transplant rates reflect expanding indications and improved access.
Clinical Best Practices
Maintain comprehensive and standardized data reporting for transplant activity to monitor trends and outcomes.
Utilize multiple donor sources including haploidentical and unrelated donors to expand transplant availability.
Implement quality control measures to ensure data accuracy and support clinical decision-making.
by J R Passweg, H Baldomero, P Bader, C Bonini, S Cesaro, P Dreger, R F Duarte, C Dufour, J Kuball, D Farge-Bancel, A Gennery, N Kröger, F Lanza, A Nagler, A Sureda, M Mohty
