Childhood-onset systemic lupus erythematosus presenting with growth retardation and delayed puberty: a case report
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By
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Yumo Liu
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Xinyu Li
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Zhengnan Gao
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Xuhan Liu
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May 25, 2026
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Clinical Scorecard: Systemic Lupus Erythematosus with Childhood Onset: A Case of Growth Delays and Puberty Deferral
At a Glance
| Category | Detail |
|---|
| Condition | Childhood-onset systemic lupus erythematosus (cSLE) |
| Key Mechanisms | Chronic inflammation, glucocorticoid exposure, disruption of GH–IGF-1 and hypothalamic–pituitary–gonadal axes |
| Target Population | Children and adolescents with unexplained growth retardation or delayed puberty |
| Care Setting | Endocrinology clinic |
Key Highlights
- cSLE accounts for 15%-20% of all SLE cases, with a peak onset age of 10-13 years.
- Atypical presentations such as growth retardation and delayed puberty may delay diagnosis.
- Immunosuppressive therapy can improve systemic manifestations but may not resolve growth and pubertal issues.
- Early recognition and multidisciplinary management are essential for better outcomes.
Guideline-Based Recommendations
Diagnosis
- Consider cSLE in adolescents with unexplained short stature or pubertal delay, especially with proteinuria or immunological abnormalities.
Management
- Implement immunosuppressive therapy for systemic manifestations.
Monitoring & Follow-up
- Longitudinal follow-up for growth and pubertal progression.
Risks
- Growth impairment may persist despite disease control.
Patient & Prescribing Data
Children with cSLE presenting with growth and pubertal delays.
Immunosuppressive therapy is effective for systemic symptoms but may not fully address growth issues.
Clinical Best Practices
- Conduct comprehensive growth assessments in children with suspected cSLE.
- Utilize multidisciplinary approaches for management.
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