Predictive Models Using Interpretable Machine Learning for Cardiovascular Survival in Breast Cancer Patients with Secondary Malignancies: Insights from a SEER Analysis - Scorecard - MDSpire

Predictive Models Using Interpretable Machine Learning for Cardiovascular Survival in Breast Cancer Patients with Secondary Malignancies: Insights from a SEER Analysis

  • By

  • Wen Shui

  • Chao Lan

  • Xueqing Xing

  • Jian Wang

  • Huiping Liu

  • March 1, 2026

  • 0 min

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Clinical Scorecard: Predictive Models Using Interpretable Machine Learning for Cardiovascular Survival in Breast Cancer Patients with Secondary Malignancies: Insights from a SEER Analysis

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationBreast cancer survivors aged 18 and older with second primary cancers diagnosed between 2010 and 2021
Care Setting

Key Highlights

  • Machine learning models (RSF, SVM, XGBoost, DeepSurv) outperform traditional statistical methods in predicting cardiovascular survival

Guideline-Based Recommendations

Diagnosis

    Management

    • Implement proactive management strategies for cardiovascular complications, including regular screenings and tailored treatment plans.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Consideration of treatment modalities including surgery, radiotherapy, and chemotherapy, along with their associated cardiovascular risks.

        Clinical Best Practices

        • Adopt a multidisciplinary approach involving oncologists, cardiologists, and primary care providers to manage both cancer and cardiovascular health.

        References

        Original Source(s)

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