Diagnostic accuracy of modern imaging following neoadjuvant therapy for breast cancer: a comparative analysis of ultrasound versus [18F] FDG PET/MRI in breast response assessment - Scorecard - MDSpire

Diagnostic accuracy of modern imaging following neoadjuvant therapy for breast cancer: a comparative analysis of ultrasound versus [18F] FDG PET/MRI in breast response assessment

  • By

  • Rosa Di Micco

  • Selin Saracoglu

  • André Pfob

  • Carla Canevari

  • Francesca Gallivanone

  • Lidija Antunovic

  • Fabrizia Gelardi

  • Paola Scifo

  • Ilaria Neri

  • Claudio Losio

  • Elena Venturini

  • Giovanna Della Vecchia

  • Goffredo Ferrarese

  • Nicole Rotmensz

  • Veronica Zuber

  • Sara Baleri

  • Giovanni Cisternino

  • Silvia Paola Corona

  • Francesca Calabretto

  • Mario Rampa

  • Luca Licata

  • Giulia Viale

  • Stefania Zambelli

  • Isabella Sassi

  • Giampaolo Bianchini

  • Pietro Panizza

  • Arturo Chiti

  • Joerg Heil

  • Oreste Davide Gentilini

  • June 18, 2026

  • 0 min

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Clinical Scorecard: Evaluating the Diagnostic Performance of Ultrasound versus [18F] FDG PET/MRI for Assessing Breast Cancer Response After Neoadjuvant Therapy

At a Glance

CategoryDetail
ConditionBreast Cancer
Key MechanismsAssessment of pathological complete response (pCR) after primary systemic therapy (PST)
Target PopulationPatients with breast cancer undergoing PST
Care SettingMulticenter analysis including prospective and retrospective cohorts

Key Highlights

  • [18F]FDG PET/MRI showed sensitivity of 62% and specificity of 67%.
  • Ultrasound demonstrated sensitivity of 59% and specificity of 62%.
  • No significant difference in diagnostic accuracy between [18F]FDG PET/MRI and ultrasound.
  • Sensitivity varied by tumor subtype, with ultrasound at 73% for triple-negative tumors.

Guideline-Based Recommendations

Diagnosis

  • Use ultrasound and [18F]FDG PET/MRI to assess breast response to PST.

Management

    Monitoring & Follow-up

    • Monitor for residual disease post-PST using imaging modalities.

    Risks

    • Operator dependency of ultrasound may limit reproducibility.

    Patient & Prescribing Data

    143 patients from two cohorts (54 from San Raffaele Hospital, 89 from Heidelberg Hospital).

    Achieving pCR is associated with improved overall and disease-free survival.

    Clinical Best Practices

      Related Resources & Content

      Original Source(s)

      Diagnostic accuracy of modern imaging following neoadjuvant therapy for breast cancer: a comparative analysis of ultrasound versus [18F] FDG PET/MRI in breast response assessment

      • by Rosa Di Micco, Selin Saracoglu, André Pfob, Carla Canevari, Francesca Gallivanone, Lidija Antunovic, Fabrizia Gelardi, Paola Scifo, Ilaria Neri, Claudio Losio, Elena Venturini, Giovanna Della Vecchia, Goffredo Ferrarese, Nicole Rotmensz, Veronica Zuber, Sara Baleri, Giovanni Cisternino, Silvia Paola Corona, Francesca Calabretto, Mario Rampa, Luca Licata, Giulia Viale, Stefania Zambelli, Isabella Sassi, Giampaolo Bianchini, Pietro Panizza, Arturo Chiti, Joerg Heil, Oreste Davide Gentilini

      • June 18, 2026

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