Levels of vascular endothelial growth factor and filtration surgery outcomes in diabetic patients with acute primary angle closure - Scorecard - MDSpire
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Association of Aqueous Humor Vascular Endothelial Growth Factor Levels with Filtration Surgery Results in Diabetic Patients Experiencing Acute Primary Angle Closure

  • By

  • Tianwei Qian

  • Mingshui Fu

  • Hao Zhou

  • Zhihua Zhang

  • Ying Hu

  • July 14, 2026

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Clinical Scorecard: Association of Aqueous Humor Vascular Endothelial Growth Factor Levels with Filtration Surgery Results in Diabetic Patients Experiencing Acute Primary Angle Closure

At a Glance

CategoryDetail
ConditionAcute Primary Angle Closure (APAC)
Key MechanismsIncreased aqueous humor vascular endothelial growth factor (VEGF) levels associated with surgical outcomes.
Target PopulationDiabetic patients with a history of APAC.
Care SettingOphthalmic surgery and follow-up care.

Key Highlights

  • Higher aqueous humor VEGF levels correlated with surgical failure.
  • Success rate significantly higher in low-VEGF group compared to high-VEGF group.
  • VEGF levels positively correlated with bleb scores post-surgery.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis of APAC based on clinical features and intraocular pressure assessment.

Management

  • Phacoemulsification and IOL implantation combined with trabeculectomy for IOP reduction.

Monitoring & Follow-up

  • Follow-up examinations at 1 week, and 1, 3, 6, 12, and 18 months postoperatively.

Risks

  • Higher VEGF levels may indicate increased risk of surgical failure.

Patient & Prescribing Data

Diabetic individuals with controlled blood glucose and a history of APAC.

Standard antiglaucomatous medications used preoperatively.

Clinical Best Practices

  • Evaluate VEGF levels in aqueous humor as a potential marker for surgical outcomes.
  • Ensure thorough ophthalmic examination and patient selection prior to surgery.

Related Resources & Content

Original Source(s)

Levels of vascular endothelial growth factor and filtration surgery outcomes in diabetic patients with acute primary angle closure

  • by Tianwei Qian, Mingshui Fu, Hao Zhou, Zhihua Zhang, Ying Hu

  • July 14, 2026

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