Editorial: Ovarian aging: pathophysiology and recent development of maintaining ovarian reserve, volume IV
By
Osamu Wada-Hiraike
Michio Kitajima
Antonio Simone Laganà
June 11, 2026
Clinical Scorecard: Understanding Ovarian Aging: Mechanisms and Recent Advances in Preserving Ovarian Reserve, Volume IV
At a Glance
Category Detail
Condition Ovarian Aging Key Mechanisms Follicular depletion, mitochondrial dysfunction, oxidative stress, inflammatory biomarkers Target Population Women experiencing age-related decline in fertility and primary ovarian insufficiency (POI) Care Setting Reproductive medicine and assisted reproductive technology (ART)
Key Highlights
Ovarian aging involves both quantitative and qualitative decline in ovarian reserve. Emerging strategies include antioxidant therapies, hormonal modulation, and ovarian tissue cryopreservation. Ovarian reserve is influenced by the inflammatory microenvironment surrounding oocytes. Growth hormone may improve outcomes in patients with diminished ovarian reserve. Mathematical models can predict ART outcomes based on oocyte quality and quantity. Guideline-Based Recommendations
Diagnosis
Assess ovarian reserve using markers such as AMH and AFC. Management
Consider hormonal modulation and growth factor interventions for preserving ovarian function. Monitoring & Follow-up
Monitor inflammatory biomarkers and oocyte quality in ART settings. Risks
Be aware of oxidative stress and its impact on oocyte and embryo quality. Patient & Prescribing Data
Women with diminished ovarian reserve or undergoing ART.
Growth hormone and antioxidant strategies may be beneficial but require careful patient selection.
Clinical Best Practices
Utilize individualized prediction models for reproductive counseling. Implement standardized protocols for growth hormone therapy in ART. Related Resources & Content
