Case Report: CLAPO syndrome: a case management and literature review
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By
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Liang Wang
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Ming Wang
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Xiaojuan Li
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Bingxuan Jiao
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Dan Song
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July 8, 2026
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Clinical Scorecard: Clinical Insights into CLAPO Syndrome: A Case Study and Review of Existing Literature
At a Glance
| Category | Detail |
|---|
| Condition | CLAPO syndrome |
| Key Mechanisms | Associated with PIK3CA-related overgrowth spectrum and characterized by capillary malformation, lymphatic malformation, and tissue overgrowth. |
| Target Population | Patients with capillary malformation of the lower lip and associated vascular malformations. |
| Care Setting | Clinical evaluation and management of rare vascular malformations. |
Key Highlights
- All 31 patients exhibited lower lip capillary malformation.
- Lymphatic malformations were observed in 25 cases.
- Venous malformations were reported in 17 cases.
- Overgrowth was present in 10 patients.
- Sclerotherapy showed clinical efficacy in treatment.
Guideline-Based Recommendations
Diagnosis
- Raise suspicion of CLAPO syndrome in patients with lower lip capillary malformation.
Management
- Sclerotherapy is effective for managing vascular malformations.
Monitoring & Follow-up
- Monitor for development of lymphatic and venous malformations.
Risks
- Potential for underdiagnosis due to rarity.
Patient & Prescribing Data
Patients with clinical features of CLAPO syndrome, primarily children.
Sclerotherapy and pulsed dye laser have shown efficacy in treatment.
Clinical Best Practices
- Consider genetic testing for patients with suspected CLAPO syndrome.
- Document and monitor vascular malformations over time.
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