Brief report: joint trajectories of anxiety and depression symptoms in an inception cohort of autistic youth
By
Michelle C. Hunsche
Anat Zaidman-Zait
Melissa Olana
Peter Szatmari
Teresa Bennett
Eric Duku
Stelios Georgiades
Isabel M. Smith
Lonnie Zwaigenbaum
Mayada Elsabbagh
Tracy Vaillancourt
Rachael Bedford
Connor M. Kerns
May 5, 2026
Clinical Scorecard: Short report: Concurrent development of anxiety and depression symptoms in a cohort of autistic adolescents
At a Glance
Category Detail
Condition Anxiety and Depression in Autistic Youth
Key Mechanisms Joint trajectories of anxiety and depression symptoms; influence of autistic traits, emotional reactivity, and communication ability.
Target Population Autistic adolescents aged 7-16 years.
Care Setting Clinical and research settings focusing on mental health in autistic youth.
Key Highlights
Anxiety symptoms stable; depression symptoms increase from childhood to adolescence. Significant heterogeneity in individual trajectories of anxiety and depression. Greater autistic traits and emotional reactivity correlate with higher initial anxiety and depression symptoms. Stronger communication ability linked to more initial anxiety but decreasing symptoms over time. Importance of joint monitoring of anxiety and depression for early detection and intervention.
Guideline-Based Recommendations
Diagnosis
Utilize caregiver-reported measures for assessing anxiety and depression symptoms.
Management
Implement early intervention strategies targeting both anxiety and depression symptoms.
Monitoring & Follow-up
Regularly monitor changes in anxiety and depression symptoms during the transition to adolescence.
Risks
Consider the impact of emotional reactivity and communication ability on mental health outcomes.
Patient & Prescribing Data
Autistic youth with varied communication abilities.
Focus on addressing both anxiety and depression symptoms concurrently.
Clinical Best Practices
Adopt a holistic approach to mental health care for autistic youth. Encourage collaboration between caregivers and healthcare providers for symptom monitoring. Tailor interventions based on individual trajectories of anxiety and depression.
References