Accidental alcohol ingestion triggering severe disulfiram-like reaction in a child receiving cefoperazone-sulbactam: a rare case report - Scorecard - MDSpire
Advertisement
Accidental alcohol ingestion triggering severe disulfiram-like reaction in a child receiving cefoperazone-sulbactam: a rare case report
Clinical Scorecard: Severe Disulfiram-like Reaction Induced by Accidental Alcohol Consumption in a Child Treated with Cefoperazone-Sulbactam: An Uncommon Case Study
At a Glance
Category
Detail
Condition
Key Mechanisms
Inhibition of hepatic aldehyde dehydrogenase (ALDH) by cephalosporins containing a methyltetrazolethiol (MTT) side chain.
Target Population
Care Setting
Key Highlights
Accidental alcohol consumption can trigger CIDLR in children.
Symptoms may include hypotension, tachycardia, and shock.
Guideline-Based Recommendations
Diagnosis
Consider CIDLR in pediatric patients receiving MTT-containing cephalosporins who present with shock after alcohol ingestion.
Management
Discontinue cefoperazone-sulbactam immediately upon suspicion of CIDLR.
Monitoring & Follow-up
Monitor vital signs and clinical status closely after suspected CIDLR.
Risks
Risk of life-threatening shock and other severe symptoms following alcohol consumption during treatment.
Patient & Prescribing Data
Children treated with cefoperazone-sulbactam for infections.
Awareness of potential interactions with alcohol is crucial.
Clinical Best Practices
Educate caregivers about the risks of alcohol consumption during treatment.
