Inhibitory impact of A1 and A2 cow’s milk on human peripheral blood mononuclear cells identifies TOM1 as a candidate anti-inflammatory mediator - Scorecard - MDSpire

Inhibitory impact of A1 and A2 cow’s milk on human peripheral blood mononuclear cells identifies TOM1 as a candidate anti-inflammatory mediator

  • By

  • Lili M. Flad

  • Tanja Weißer

  • Jonas Liedl

  • Felix Gard

  • Agnese Petrera

  • Christine von Toerne

  • Stefanie M. Hauck

  • Cornelia A. Deeg

  • Kristina J. H. Kleinwort

  • June 10, 2026

  • 0 min

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Clinical Scorecard: Effects of A1 and A2 Cow's Milk on Human Peripheral Blood Mononuclear Cells Highlight TOM1 as a Potential Anti-Inflammatory Mediator

At a Glance

CategoryDetail
Condition
Key MechanismsInhibition of PBMC proliferation by high molecular weight fractions of A1 and A2 milk.
Target Population
Care Setting

Key Highlights

  • A1 and A2 milk inhibit Concanavalin A-induced PBMC proliferation.
  • High molecular weight fractions (HWF) of milk are responsible for the inhibitory effect.
  • TOM1 protein is significantly increased in PBMC supernatants after exposure to HWFs.

Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

        Risks

          Patient & Prescribing Data

          Not specified

          Potential use of TOM1 as an anti-inflammatory mediator derived from milk.

          Clinical Best Practices

            Related Resources & Content

              Original Source(s)

              Inhibitory impact of A1 and A2 cow’s milk on human peripheral blood mononuclear cells identifies TOM1 as a candidate anti-inflammatory mediator

              • by Lili M. Flad, Tanja Weißer, Jonas Liedl, Felix Gard, Agnese Petrera, Christine von Toerne, Stefanie M. Hauck, Cornelia A. Deeg, Kristina J. H. Kleinwort

              • June 10, 2026

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