Assessment of Anterior Scleral Thickness in Acromegaly: A Prospective Multinational Optical Coherence Tomography Study
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By
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Başak Memis
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Murat Kasikci
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Gulhan Akbaba
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Ozgur Erogul
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February 12, 2026
Clinical Scorecard: Assessment of Anterior Scleral Thickness in Acromegaly: A Prospective Multinational Optical Coherence Tomography Study
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | Adults aged ≥ 18 years with biochemically confirmed acromegaly, meeting specific inclusion criteria. |
| Care Setting | |
Key Highlights
- First systematic assessment of anterior scleral thickness in acromegaly.
- Significant scleral remodeling linked to GH/IGF-1 activity.
- Potential implications for glaucoma susceptibility and surgical outcomes.
- Methodology includes high-resolution AS-OCT imaging.
Guideline-Based Recommendations
Diagnosis
Management
- Treatment status categorized as untreated, medically controlled, surgically treated, or combined therapy, with specific indications for each.
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Treatment may include somatostatin analogs or dopamine agonists, particularly in cases of uncontrolled GH secretion.
Clinical Best Practices
- Conduct detailed ophthalmologic evaluations in acromegaly patients.
- Utilize AS-OCT for accurate measurement of scleral thickness.
- Establish a follow-up frequency for regular ocular health assessments.
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