Microbiota metabolite butyrate alleviates intestinal inflammation associated with enhanced autophagy-related signaling in DSS-induced colitis
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By
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Qingyi Mao
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Beibei Lin
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Wenluo Zhang
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Yu Zhang
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Yue Lei
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Zhou Zhang
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Mengque Xu
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June 17, 2026
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Clinical Scorecard: Butyrate from Gut Microbiota Reduces Intestinal Inflammation by Enhancing Autophagy Signaling in DSS-Induced Colitis
At a Glance
| Category | Detail |
|---|
| Condition | Inflammatory Bowel Disease (IBD) |
| Key Mechanisms | Butyrate enhances autophagy signaling and restores intestinal barrier function. |
| Target Population | Patients with inflammatory bowel disease (IBD) and experimental colitis models. |
| Care Setting | Clinical and experimental research settings. |
Key Highlights
- Butyrate levels are significantly lower in IBD patients compared to healthy controls.
- Oral sodium butyrate treatment improves gut microbiota composition and intestinal barrier function.
- Enhanced autophagy signaling is observed with butyrate treatment, while autophagy inhibition diminishes protective effects.
- Dysbiosis characterized by reduced Firmicutes/Bacteroidetes ratio is noted in IBD.
- Autophagy inducers may serve as potential therapeutic agents for gut inflammation.
Guideline-Based Recommendations
Diagnosis
- Assess butyrate levels and gut microbiota composition in IBD patients.
Management
- Consider sodium butyrate supplementation to restore gut microbiota and enhance autophagy.
Monitoring & Follow-up
- Monitor changes in intestinal barrier function and autophagy markers in response to treatment.
Risks
- Inhibition of autophagy may exacerbate colonic injury in IBD.
Patient & Prescribing Data
Individuals diagnosed with inflammatory bowel disease (IBD).
Sodium butyrate may improve clinical outcomes by modulating gut microbiota and enhancing autophagy.
Clinical Best Practices
- Integrate dietary interventions to increase butyrate-producing probiotics.
- Evaluate the role of autophagy in the management of IBD.
- Utilize fecal SCFA profiling for personalized treatment strategies.
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