Submucosal uterine leiomyoma with complete cystic degeneration mimicking an empty gestational sac: a case report and literature review - Scorecard - MDSpire

Submucosal uterine leiomyoma with complete cystic degeneration mimicking an empty gestational sac: a case report and literature review

  • By

  • Shunlin Lin

  • Di An

  • Zihua Xu

  • June 26, 2026

  • 0 min

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Clinical Scorecard: Cystic Degeneration of Submucosal Uterine Leiomyoma Resembling an Empty Gestational Sac: A Case Study and Review of Existing Literature

At a Glance

CategoryDetail
ConditionCystic Degeneration of Submucosal Uterine Leiomyoma
Key MechanismsCystic transformation due to intratumoral ischemia and necrosis.
Target PopulationWomen of reproductive age, particularly those presenting with irregular vaginal bleeding.
Care SettingOutpatient gynecological clinic and surgical intervention setting.

Key Highlights

  • Cystic degeneration of submucosal leiomyoma can mimic an empty gestational sac.
  • Negative serum β-hCG is crucial for diagnosis.
  • Hysteroscopy is essential for both diagnosis and treatment.
  • Immunohistochemistry aids in definitive diagnosis.
  • Follow-up imaging confirmed absence of recurrence.

Guideline-Based Recommendations

Diagnosis

  • Consider cystic submucosal leiomyoma in differential diagnosis of intracavitary cystic lesions.
  • Utilize serum β-hCG testing to rule out pregnancy-related conditions.

Management

  • Employ hysteroscopic resection for definitive treatment.

Monitoring & Follow-up

  • Conduct follow-up imaging to assess for recurrence.

Risks

  • Misdiagnosis as an empty gestational sac or other cystic lesions.

Patient & Prescribing Data

42-year-old parous woman with irregular vaginal bleeding.

Electrosurgical resection of the cystic leiomyoma was performed.

Clinical Best Practices

  • Perform thorough diagnostic evaluations for atypical presentations.
  • Utilize hysteroscopy for direct visualization and treatment of intracavitary lesions.
  • Incorporate immunohistochemical analysis when histopathology is inconclusive.

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