Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis
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By
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Akram Alnounou
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Henry Zou
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Madison C. Laird
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Sophie Numbers
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Christopher Visak
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Sage Bilsland
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Neil Hughes
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Eric Martin Sieloff
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April 17, 2026
Clinical Scorecard: Clinical Case Study: Autoimmune Hemolytic Anemia and Hepatitis Triggered by EBV-Related Infectious Mononucleosis
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | |
| Target Population | Adolescents and young adults (ages 12-25), particularly previously healthy individuals |
| Care Setting | |
Key Highlights
- Patient showed clinical improvement over five days of hospitalization.
Guideline-Based Recommendations
Diagnosis
- Conduct a broad diagnostic workup including viral serologies and autoimmune markers (e.g., ANA, anti-dsDNA).
- Utilize imaging studies to exclude biliary obstruction.
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Cautious use of steroids is advised due to the risk of immunosuppression, particularly in the context of AIHA.
Clinical Best Practices
- Recognize atypical presentations of EBV infection.
- Implement a multidisciplinary approach involving gastroenterology and hematology/oncology.
- Provide follow-up care recommendations post-discharge.
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