Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy - Scorecard - MDSpire

Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy

  • By

  • Laura Scholz

  • Nils Hoymann

  • Suzan Alboradi

  • Valeriia Grabar

  • Gina Marie Uehre

  • George Toth

  • József Mészáros

  • Paolo Gennari

  • Svetlana Tchaikovski

  • Atanas Ignatov

  • Mandy Busse

  • June 16, 2026

  • 0 min

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Clinical Scorecard: In-depth Analysis of B Cell Subpopulations in Pregnant Women After SARS-CoV-2 Vaccination and Infection

At a Glance

CategoryDetail
Condition
Key MechanismsAlterations in B cell populations and specific cytokine levels (e.g., IL-10, IL-6) observed post-vaccination and infection.
Target Population
Care Setting

Key Highlights

  • Significant shifts in B cell populations observed post-vaccination and infection, with implications for maternal immunity.
  • Increased IL-10+ B cells and decreased IL-6+ B cells in infected women compared to vaccinated women, indicating altered immune response.
  • Vaccination enhances expression of PD-1, FasL, and CD86 in B cells, suggesting a shift towards a regulatory phenotype.
  • Need for further investigation into long-term maternal and offspring immunity, particularly regarding B cell memory.
  • Pregnant women are at elevated risk for complications from respiratory viral infections, necessitating tailored vaccination strategies.

Guideline-Based Recommendations

Diagnosis

    Management

    • Consider annual vaccination against SARS-CoV-2 for pregnant women, supported by evidence of increased risk from infection.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Vaccination alters B cell populations and cytokine responses, which may inform clinical management of pregnant patients.

        Clinical Best Practices

        • Monitor immune responses in pregnant women following SARS-CoV-2 vaccination and infection using specific cytokine assays and flow cytometry.
        • Evaluate the balance between pro- and anti-inflammatory B cell populations through comprehensive immune profiling.

        Related Resources & Content

        Original Source(s)

        Detailed investigation of B cell populations following vaccination and infection with severe acute respiratory syndrome coronavirus-2 during pregnancy

        • by Laura Scholz, Nils Hoymann, Suzan Alboradi, Valeriia Grabar, Gina Marie Uehre, George Toth, József Mészáros, Paolo Gennari, Svetlana Tchaikovski, Atanas Ignatov, Mandy Busse

        • June 16, 2026

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