Machine learning for oral frailty factors in hospitalized schizophrenia patients: two-stage feature selection and SHAP analysis - Scorecard - MDSpire

Utilizing Machine Learning to Identify Oral Frailty Determinants in Hospitalized Patients with Schizophrenia: A Two-Stage Feature Selection and SHAP Analysis Approach

  • By

  • Yue Fu

  • Xing Yang

  • Tao Zhang

  • Yingying Wang

  • Shihan Tang

  • Zheng Luo

  • Cui Yang

  • Dongmei Wu

  • April 20, 2026

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Clinical Scorecard: Utilizing Machine Learning to Identify Oral Frailty Determinants in Hospitalized Patients with Schizophrenia: A Two-Stage Feature Selection and SHAP Analysis Approach

At a Glance

CategoryDetail
ConditionOral Frailty in Schizophrenia
Key MechanismsMachine Learning for risk factor identification and predictive modeling
Target PopulationLong-term hospitalized patients with schizophrenia
Care SettingPsychiatric hospitals

Key Highlights

  • Prevalence of Oral Frailty (OF) in this population is 69.3%
  • Random forest model achieved an AUC of 0.779 after optimization
  • Core risk factors identified include Number of Teeth, Psychiatric Hospitalizations, Self-discontinuation of Medication, Marital Status, and Age
  • Traditional regression models are limited in high-dimensional data processing
  • SHAP analysis enhances interpretability of machine learning models

Guideline-Based Recommendations

Diagnosis

  • Utilize the Oral Frailty Index-8 for assessment of OF

Management

  • Develop individualized oral intervention programs based on identified risk factors

Monitoring & Follow-up

  • Regularly assess oral health and frailty status in hospitalized SZ patients

Risks

  • Monitor for complications such as dysphagia and increased risk of aspiration pneumonia

Patient & Prescribing Data

Long-term hospitalized patients with schizophrenia

Address oral health issues through targeted interventions based on identified determinants

Clinical Best Practices

  • Implement machine learning approaches for risk assessment in oral health
  • Incorporate SHAP for model interpretability in clinical settings
  • Focus on comprehensive evaluations of oral and systemic health

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