Association of semen leukocytes with sperm DNA fragmentation in a clinical cohort
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By
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Lijun Peng
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Tengfei Wang
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Mengyi Zhu
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Yun Le
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Sheng Yang
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May 21, 2026
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Clinical Scorecard: Correlation Between Semen Leukocyte Counts and Sperm DNA Fragmentation in a Clinical Population
At a Glance
| Category | Detail |
|---|
| Condition | Sperm DNA fragmentation and male reproductive health |
| Key Mechanisms | Oxidative stress and inflammation from semen leukocytes |
| Target Population | Men undergoing semen analysis for infertility evaluation |
| Care Setting | Reproductive health clinics |
Key Highlights
- Sperm DNA fragmentation index (DFI) correlates inversely with semen motility and CASA kinematics.
- Semen leukocytes positively correlate with DFI, indicating local inflammatory activity.
- Age is a significant factor, with DFI increasing as age advances.
- Albumin shows a strong inverse correlation with DFI, suggesting systemic antioxidant status.
- A predictive model for high DFI demonstrated good internal validation.
Guideline-Based Recommendations
Diagnosis
- Utilize sperm DFI assessment in unexplained infertility and recurrent pregnancy loss.
Management
- Consider evaluating semen leukocyte counts and systemic biomarkers alongside DFI.
Monitoring & Follow-up
- Regularly assess DFI in men with known infertility issues.
Risks
- Elevated DFI is associated with lower clinical pregnancy rates and higher pregnancy loss.
Patient & Prescribing Data
Men undergoing fertility assessments in clinical settings.
Incorporate DFI and leukocyte counts in fertility evaluations to improve diagnostic accuracy.
Clinical Best Practices
- Integrate CASA kinematic data with DFI for enhanced semen analysis interpretation.
- Adhere to WHO guidelines for standardized semen analysis protocols.
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