Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation
By
Zekai Hu
Jinyan Wang
Sicong Ma
Jie Zhuang
Jing Shi
Yan Zhu
May 15, 2026
Clinical Scorecard: Metabolic Reprogramming and Immune System Changes in Chronic Fatigue: Understanding GPCR Signaling and Epigenetic Modifications
At a Glance
Category Detail
Condition Key Mechanisms Mitochondrial dysfunction, altered glycolysis, GPCR signaling, epigenetic acylation, immune remodeling (linked to chronic fatigue) Target Population Care Setting
Key Highlights
Chronic fatigue is linked to inflammation and metabolic dysregulation. GPCR signaling plays a crucial role in mediating inflammatory and metabolic responses. Metabolic reprogramming in immune cells contributes to fatigue. Epigenetic modifications may influence immune function and fatigue biology. Evidence linking GPCR pathways to fatigue remains largely indirect and requires further investigation. Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Individuals with chronic fatigue due to inflammatory conditions.
Focus on reducing inflammation and improving metabolic function.
Clinical Best Practices
Integrate assessments of immune and metabolic function in fatigue evaluations, emphasizing their interconnection. Utilize a multidisciplinary approach for managing chronic fatigue. Stay updated on emerging research regarding GPCR signaling and epigenetic modifications. Related Resources & Content
