The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI - Scorecard - MDSpire
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The cardiovascular risk marker itaconate is sex-dependently associated with legume intake and immune-inflammatory competence in subjects with high BMI
Clinical Scorecard: Sex-Specific Associations of Itaconate, a Cardiovascular Risk Biomarker, with Legume Consumption and Immune-Inflammatory Function in Individuals with Elevated BMI
At a Glance
Category
Detail
Condition
Key Mechanisms
Itaconate as an immunometabolic mediator linking metabolism to inflammatory responses.
Target Population
Care Setting
Key Highlights
Itaconate levels did not differ across legume intake categories.
Higher legume consumption associated with a healthier lifestyle but not with itaconate levels.
Monocyte counts independently associated with circulating itaconate.
IL-6 showed an inverse association with itaconate levels.
Significant sex-specific differences in itaconate and immune response.
Guideline-Based Recommendations
Diagnosis
Evaluate circulating itaconate as a marker of innate immune activation.
Management
Monitoring & Follow-up
Monitor monocyte counts and IL-6 levels in relation to itaconate concentrations.
Risks
Assess sex-specific immune responses in cardiovascular risk evaluations.
Patient & Prescribing Data
Individuals with excessive adiposity
Clinical Best Practices
Incorporate assessments of dietary intake in cardiovascular risk evaluations.
Recognize the role of sex in immune function and cardiovascular health.
by Amanda Cuevas-Sierra, Andrea Higuera-Gómez, Begoña de Cuevillas, Gabriela Paula-Buestan, María Martínez-Urbistondo, Raquel Castejón, J. Antonio Vargas, José Moisés Laparra, J. Alfredo Martínez
