Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation - Scorecard - MDSpire

Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation

  • By

  • Chenglong Luo

  • Jing Li

  • Wanling Mu

  • Mengchen Yuan

  • Pengchao Zhan

  • Yiyang Liu

  • Yue Zhou

  • Liming Li

  • Changmao Ding

  • Xuejun Chen

  • Jianbo Gao

  • January 23, 2026

  • 0 min

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Clinical Scorecard: Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPatients with locally advanced AEG (clinical stage T2-4aNxM0) as confirmed by histopathology.
Care Setting

Key Highlights

  • NAC combined with surgical resection is the standard treatment for locally advanced AEG.
  • Tumor heterogeneity affects NAC efficacy, leading to variable patient outcomes.
  • Radiomics features can aid in predicting chemotherapy response and guide individualized treatment strategies.

Guideline-Based Recommendations

Diagnosis

  • Histopathologic confirmation of locally advanced AEG is required prior to NAC, including specific criteria for diagnosis.

Management

  • NAC regimens include oxaliplatin + S-1 (SOX), capecitabine + oxaliplatin (XELOX), and FLOT, with details on their administration.

Monitoring & Follow-up

  • Postoperative pathological specimens evaluated using the Becker grading system to assess tumor regression, with a brief explanation of the system.

Risks

  • Some patients may experience poor response to NAC, leading to delayed surgery and poor prognosis.

Patient & Prescribing Data

2–4 cycles of NAC (including specific regimens) are administered before radical surgical resection.

Clinical Best Practices

  • Utilize 3D contrast-enhanced CT for baseline evaluation and treatment response assessment.
  • Incorporate radiomics analysis to enhance predictive accuracy for NAC outcomes.
  • Recommend regular follow-up imaging assessments to monitor treatment response.

References

Original Source(s)

Assessing the Role of 3D Contrast-Enhanced CT Radiomics in Anticipating Neoadjuvant Chemotherapy Outcomes for Esophagogastric Junction Adenocarcinoma: Findings from a Dual-Center Investigation

  • by Chenglong Luo, Jing Li, Wanling Mu, Mengchen Yuan, Pengchao Zhan, Yiyang Liu, Yue Zhou, Liming Li, Changmao Ding, Xuejun Chen, Jianbo Gao

  • January 23, 2026

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