Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale - Scorecard - MDSpire

Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale

  • By

  • Sina Stoltefuß

  • Gabriela Leuschner

  • Tobias Veit

  • Jeremias Götschke

  • Katrin Milger

  • Teresa Kauke

  • Alexandra Lenoir

  • Nikolaus Kneidinger

  • Jürgen Behr

  • January 10, 2026

  • 0 min

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Clinical Scorecard: Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale

At a Glance

CategoryDetail
ConditionInterstitial Lung Disease (ILD)
Key MechanismsSymptoms include shortness of breath, cough, and fatigue; lung transplantation (LTx) is a potential curative treatment for severe cases.
Target PopulationPatients aged 18 and older with a diagnosis of ILD, including IPF, cHP, NSIP, and uILD.
Care SettingLMU University Hospital Munich, Germany.

Key Highlights

  • HRQoL is significantly affected by ILD symptoms and therapy-related aspects.
  • LTx can improve HRQoL in ILD patients, but improvements may decline over time due to complications.
  • Chronic lung allograft dysfunction (CLAD) affects HRQoL post-transplant.
  • The GR-Scale is a validated tool for assessing HRQoL in ILD patients.
  • PROMs provide a comprehensive understanding of patient experiences beyond objective measures.

Guideline-Based Recommendations

Diagnosis

  • Diagnosis of ILD should follow current international criteria.

Management

  • Consider lung transplantation for patients with very severe and advanced ILD.

Monitoring & Follow-up

  • Assess HRQoL using the GR-Scale at routine follow-up intervals of 3 to 6 months.

Risks

  • Monitor for CLAD, which can lead to a significant decline in HRQoL.

Patient & Prescribing Data

Patients with ILD, including those who have undergone lung transplantation.

LTx is associated with improved HRQoL initially, but may decline due to complications such as CLAD.

Clinical Best Practices

  • Utilize PROMs like the GR-Scale for a patient-centered assessment of HRQoL.
  • Regularly monitor lung function and HRQoL in post-transplant patients.

References

Original Source(s)

Evaluating Health-Related Quality of Life in Interstitial Lung Disease Patients With and Without Lung Transplantation Using the GR-Scale

  • by Sina Stoltefuß, Gabriela Leuschner, Tobias Veit, Jeremias Götschke, Katrin Milger, Teresa Kauke, Alexandra Lenoir, Nikolaus Kneidinger, Jürgen Behr

  • January 10, 2026

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