Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development - Scorecard - MDSpire

Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development

  • By

  • Shang-Yin Wu

  • Po-Chuan Chen

  • Ren-Hao Chan

  • Chung-Hsing Chen

  • Yi-Hsuan Huang

  • Yi-Jing Huang

  • Bing-Syuan Chung

  • Che-Hung Shen

  • Hsin-Yu Kuo

  • Jui-Wen Kang

  • Chung-Ta Lee

  • Hui-Ju Tsai

  • Yu-Chen Fang

  • Peng-Chan Lin

  • Yu-Min Yeh

  • Shang-Hung Chen

  • April 27, 2026

  • 0 min

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Clinical Scorecard: Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development

At a Glance

CategoryDetail
Condition
Key Mechanisms
Target PopulationPatients with microsatellite-stable (MSS) colorectal cancer
Care Setting

Key Highlights

  • SPP1 signaling from TREM1-positive myeloid cells to ACTA2-positive CAFs is identified as a potential axis of stromal–immune crosstalk, crucial for understanding immune evasion.

Guideline-Based Recommendations

Diagnosis

    Management

    • Focus on understanding immune evasion mechanisms, such as PD-L1 expression and cytokine profiles, to improve therapeutic outcomes in MSS CRC.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Targeting the TREM1-CAFs axis may enhance therapeutic efficacy in MSS CRC, potentially through combination therapies.

        Clinical Best Practices

        • Incorporate single-cell RNA sequencing for detailed characterization of the tumor microenvironment, focusing on myeloid cell and CAF interactions.

        References

        Original Source(s)

        Single-cell investigations uncover interactions between TREM1-expressing myeloid cells and cancer-associated fibroblasts during colorectal cancer development

        • by Shang-Yin Wu, Po-Chuan Chen, Ren-Hao Chan, Chung-Hsing Chen, Yi-Hsuan Huang, Yi-Jing Huang, Bing-Syuan Chung, Che-Hung Shen, Hsin-Yu Kuo, Jui-Wen Kang, Chung-Ta Lee, Hui-Ju Tsai, Yu-Chen Fang, Peng-Chan Lin, Yu-Min Yeh, Shang-Hung Chen

        • April 27, 2026

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