A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort - Scorecard - MDSpire
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A vitamin-biomarker risk score for 90-day functional outcome after acute ischemic stroke: development and internal validation in a retrospective cohort
Clinical Scorecard: Development and Internal Validation of a Vitamin-Based Risk Score for Predicting 90-Day Functional Outcomes Following Acute Ischemic Stroke: A Retrospective Cohort Study
At a Glance
Category
Detail
Condition
Key Mechanisms
Vitamin-related biomarkers associated with oxidative stress, inflammation, endothelial function, coagulation, and neurorepair.
Target Population
Care Setting
Key Highlights
Study included 655 AIS patients with a mean age of 66.84 years.
Poor outcome defined as mRS score of 3–6; good outcome as mRS ≤ 2.
Vitamin D, E, A, K1, B12, folate, and homocysteine identified as independent predictors of poor outcomes.
Nomogram showed good discrimination with AUC of 0.878 in training set and 0.880 in test set.
Internal validation performed with 1,000 bootstrap resamples.
Guideline-Based Recommendations
Diagnosis
Acute ischemic stroke diagnosed via clinical presentation and imaging (CT/MRI).
Management
Utilize vitamin-related biomarkers for early risk stratification.
Monitoring & Follow-up
Monitor 3-month functional outcomes using the modified Rankin Scale (mRS).
Risks
Consider comorbidities and factors affecting vitamin absorption/metabolism.
Patient & Prescribing Data
Patients with acute ischemic stroke admitted within 24 hours of symptom onset.
Vitamin-related biomarkers may assist in predicting functional outcomes.
