Impact of Cannabis Edibles Combined With Alcohol on Driving, Field Sobriety Performance, and Subjective
By
C. Austin Zamarripa
Spencer Lin
McKenna Klausner
Kriti Rastogi
Daniel J. O. Roche
Matthew Novak
Denis Antoine
David Wolinsky
Thomas D. Marcotte
Elise M. Weerts
Ryan Vandrey
Tory R. Spindle
May 1, 2026
Clinical Scorecard: Effects of Concurrent Use of Cannabis Edibles and Alcohol on Driving Ability, Field Sobriety Tests, and Personal Perceptions
At a Glance
Category Detail
Condition Co-use of cannabis edibles and alcohol Key Mechanisms Pharmacokinetic interactions and delayed effects of cannabis edibles Target Population Healthy adults aged 21-55 with recent binge drinking and prior co-use experience Care Setting Outpatient experimental sessions
Key Highlights
Co-use of cannabis edibles and alcohol leads to greater driving impairment than solo use. Cannabis edibles produce delayed but prolonged psychoactive effects compared to smoking. Study examines multiple THC doses and alcohol concentrations to assess impairment. Guideline-Based Recommendations
Diagnosis
Assess driving impairment through simulated driving tests and field sobriety assessments. Management
Monitor individuals for impairment after co-use of cannabis edibles and alcohol. Monitoring & Follow-up
Evaluate blood THC levels and behavioral performance post-consumption. Risks
Increased risk of motor vehicle accidents due to impaired driving ability. Patient & Prescribing Data
Healthy adults with a history of binge drinking and cannabis use.
Consider the timing and sequence of cannabis and alcohol consumption in risk assessments.
Clinical Best Practices
Implement comprehensive screening for eligibility in studies involving substance use. Utilize a double-blind, placebo-controlled design to minimize bias. Ensure participants are trained on performance assessments to reduce practice effects. References
