Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis - Scorecard - MDSpire

Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis

  • By

  • Wei Kang

  • Bowie P. Y. Lam

  • Rinko Tsz Lam Lau

  • Silvia T. H. Li

  • Kangrui Wu

  • Yue Wei

  • Yu Yang

  • Kyung Jin Lee

  • Caige Huang

  • Vincent K. C. Yan

  • Hei Hang Edmund Yiu

  • Shing Fung Lee

  • Aya El Helali

  • Victor H. F. Lee

  • Stephen L. Chan

  • Rina Y. M. Hui

  • Ka On Lam

  • Esther W. Chan

  • June 15, 2026

  • 0 min

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Clinical Scorecard: Comparative Analysis of Direct Oral Anticoagulants and Low-Molecular-Weight Heparin for Thrombosis Related to Cancer: A Systematic Review and Meta-Analysis of Safety and Efficacy

At a Glance

CategoryDetail
Condition
Key MechanismsDirect oral anticoagulants (DOACs) and low-molecular-weight heparin (LMWH) are used to prevent venous thromboembolism (VTE).
Target Population
Care Setting

Key Highlights

  • DOACs associated with lower risk of recurrent VTE compared to LMWH.
  • No significant increase in major bleeding risk with DOACs.

Guideline-Based Recommendations

Diagnosis

    Management

    • Both DOACs and LMWH are recommended as first-line treatments for 3–6 months according to clinical guidelines.

    Monitoring & Follow-up

      Risks

        Patient & Prescribing Data

        Remove unsupported claims about convenience.

        Clinical Best Practices

        • Utilize a standardized methodology for study selection.

        Related Resources & Content

        Original Source(s)

        Safety and Effectiveness of Direct Oral Anticoagulants Versus Low-Molecular-Weight Heparin for Cancer-Associated Thrombosis: A Systematic Review and Meta-analysis

        • by Wei Kang, Bowie P. Y. Lam, Rinko Tsz Lam Lau, Silvia T. H. Li, Kangrui Wu, Yue Wei, Yu Yang, Kyung Jin Lee, Caige Huang, Vincent K. C. Yan, Hei Hang Edmund Yiu, Shing Fung Lee, Aya El Helali, Victor H. F. Lee, Stephen L. Chan, Rina Y. M. Hui, Ka On Lam, Esther W. Chan

        • June 15, 2026

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